Mariko Yagi Selected Research

Wasting Syndrome (Wasting Disease)

2/2017	2'-O-Methyl RNA/Ethylene-Bridged Nucleic Acid Chimera Antisense Oligonucleotides to Induce Dystrophin Exon 45 Skipping.
4/2016	Next-generation sequencing discloses a nonsense mutation in the dystrophin gene from long preserved dried umbilical cord and low-level somatic mosaicism in the proband mother.
8/2013	A prostaglandin D2 metabolite is elevated in the urine of Duchenne muscular dystrophy patients and increases further from 8 years old.
3/2012	Categorization of 77 dystrophin exons into 5 groups by a decision tree using indexes of splicing regulatory factors as decision markers.
1/2011	Chemical treatment enhances skipping of a mutated exon in the dystrophin gene.
4/2007	Two novel missense mutations in the myostatin gene identified in Japanese patients with Duchenne muscular dystrophy.
5/2006	Intravenous infusion of an antisense oligonucleotide results in exon skipping in muscle dystrophin mRNA of Duchenne muscular dystrophy.

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Mariko Yagi Research Topics

Disease

28	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 02/2017 - 01/2002
7	Wasting Syndrome (Wasting Disease) 02/2017 - 05/2006
5	Muscular Dystrophies (Muscular Dystrophy) 04/2016 - 12/2006
3	Menkes Kinky Hair Syndrome (Menkes Disease) 01/2015 - 05/2014
2	Neonatal-onset citrullinemia type 2 01/2019 - 01/2018
2	Insulin Resistance 10/2010 - 12/2009
2	Breast Neoplasms (Breast Cancer) 08/2010 - 01/2007
1	Cerebral Palsy (Spastic Diplegia) 01/2020
1	Adult-onset citrullinemia type 2 01/2018
1	Hypercholesterolemia 01/2018
1	Body Weight (Weight, Body) 10/2014
1	Bronchopulmonary Dysplasia 03/2014
1	Hereditary pancreatitis 10/2013
1	Pancreatitis 10/2013
1	Inflammation (Inflammations) 08/2013
1	Intellectual Disability (Idiocy) 01/2013
1	Rhabdomyolysis 12/2011
1	Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy) 10/2010
1	Hyperammonemia 10/2010
1	type 2C Limb-girdle muscular dystrophy 03/2010
1	Hypertrophy 04/2007
1	Isochromosomes 01/2007
1	tetrasomy 9p Chromosome 9 01/2007
1	Ornithine Carbamoyltransferase Deficiency Disease 01/2007
1	Lymphoma (Lymphomas) 01/2007
1	Klinefelter Syndrome (Klinefelter's Syndrome) 01/2007
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2007
1	46,XY Disorder of Sex Development (Male Pseudohermaphroditism) 06/2006
1	Neoplasms (Cancer) 10/2005
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2005
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2005

Drug/Important Bio-Agent (IBA)

29	DystrophinIBA 02/2017 - 01/2002
7	Messenger RNA (mRNA)IBA 02/2015 - 01/2002
5	Antisense OligonucleotidesIBA 02/2015 - 08/2004
5	Nonsense Codon (Nonsense Mutation)IBA 07/2011 - 03/2004
3	copper histidineIBA 01/2015 - 05/2014
3	Proteins (Proteins, Gene)FDA Link 01/2011 - 01/2007
2	Urea (Carbamide)FDA LinkGeneric 01/2019 - 01/2007
2	citrinIBA 01/2019 - 01/2018
2	EnzymesIBA 01/2015 - 08/2010
2	Reduced Folate Carrier ProteinIBA 08/2010 - 01/2007
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 08/2010 - 01/2007
2	Glutathione Transferase (Glutathione S-Transferase)IBA 08/2010 - 01/2007
2	MyostatinIBA 05/2008 - 04/2007
1	SolutionsIBA 01/2020
1	Aspartic Acid (Aspartate)FDA Link 01/2019
1	Amino Acid Transport System X-AG (Glutamate Transporter)IBA 01/2019
1	Amino Acids FDA Link 01/2019
1	CarbohydratesIBA 01/2019
1	LipidsIBA 01/2018
1	CholesterolIBA 01/2018
1	SterolsIBA 01/2018
1	Dopamine (Intropin)FDA LinkGeneric 01/2015
1	CopperIBA 01/2015
1	Homovanillic AcidIBA 01/2015
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2015
1	Vanilmandelic Acid (Vanillylmandelic Acid)IBA 01/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2014
1	Kazal Pancreatic Trypsin InhibitorIBA 10/2013
1	Prostaglandin D2IBA 08/2013
1	11,15- dioxo- 9- hydroxy- 2,3,4,5- tetranorprostan- 1,20- dioic acidIBA 08/2013
1	acylcarnitineIBA 12/2011
1	RNA Precursors (Precursor, mRNA)IBA 10/2011
1	Creatine Kinase (Creatine Phosphokinase)IBA 10/2010
1	Anticonvulsants (Antiepileptic Drugs)IBA 10/2010
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2010
1	AdiponectinIBA 10/2010
1	Valproic Acid (Depakote)FDA LinkGeneric 10/2010
1	Carbamyl Phosphate (Carbamoyl Phosphate)IBA 10/2010
1	LeptinIBA 10/2010
1	Pharmaceutical PreparationsIBA 08/2010
1	Sarcoglycans (beta Sarcoglycan)IBA 03/2010
1	Codon (Codons)IBA 03/2010
1	Glucose (Dextrose)FDA LinkGeneric 12/2009
1	Testosterone (Sustanon)FDA Link 01/2007
1	Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)IBA 01/2007
1	Methotrexate (Mexate)FDA LinkGeneric 01/2007
1	DNA (Deoxyribonucleic Acid)IBA 01/2007
1	Genetic Markers (Genetic Marker)IBA 01/2007
1	GonadotropinsIBA 01/2007
1	Androgen Receptors (Androgen Receptor)IBA 06/2006
1	OligodeoxyribonucleotidesIBA 10/2005
1	Gefitinib (Iressa)FDA Link 10/2005
1	ErbB Receptors (EGF Receptor)IBA 10/2005
1	RNA (Ribonucleic Acid)IBA 08/2004
1	Nucleic AcidsIBA 08/2004
1	ethyleneIBA 08/2004
1	Gentamicins (Gentamicin)FDA LinkGeneric 03/2004
1	NucleotidesIBA 01/2002

Therapy/Procedure

6	Therapeutics 03/2012 - 12/2006
2	Injections 01/2015 - 05/2014
1	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 01/2018
1	Ligation 06/2009
1	Intravenous Infusions 05/2006